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capC [2018-10-10 13:09:59]
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capC [2018-10-10 13:09:59]

capsular polyglutamate biosynthesis
locus
BSU35890
pI
9.67
mw
16.16 kDa
protein length
149 aa Sequence Blast
gene length
447 bp Sequence Blast
function
capsule synthesis
product
unknown
essential
no
synonyms
ywtA,pgsC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.4|Capsule biosynthesis and degradation]

    • Gene

    Coordinates
    3,698,982 → 3,699,431

    Phenotypes of a mutant

  • no synthesis of the poly-gamma-glutamate capsule [Pubmed|11751809]

    • Expression and Regulation

    Operons

    genes
    [gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]
    description
    [Pubmed|11751809]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|19420703], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]-P, [Pubmed|19734658], in [regulon|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU regulon]

    • additional information

  • expression of the operon is increased in '[protein|search|motA]' or '[protein|search|motB]' mutants due to increased [protein|search|DegU] phosphorylation [PubMed|24296669]
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    Biological materials

    Mutant

  • MGNA-A076 (ywtA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/76 NBRP B. subtilis, Japan]
  • BKE35890 (Δ[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE35890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCCGAACATGTCTGCATTTC, downstream forward: _UP4_ATTTAATGTAAGGTGTGTCA
  • BKK35890 (Δ[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK35890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCCGAACATGTCTGCATTTC, downstream forward: _UP4_ATTTAATGTAAGGTGTGTCA

    • References

    Reviews

  • 20735481,16689787,29215550

    • Original publications

  • 11751809,19420703,16233197,20564357,20564574,24296669,21965392,27073802,29971620